Saturday, June 18, 2011
In 18 sheep postmenopausal osteoarthritis developed following the withdrawal of the knee meniscus cartilage. After three months of the AWES (sheep) were divided into three groups. One group was evaluated for measuring the development of osteoarthritis prior to treatment. The other two groups hyaluronic acid alone in one knee and hyaluronic acid as well as allogeneic stem cells in another knee. Six months after the single injection, knees that received stem cells cartilage 20-25 percent thicker, and an enlarged area of the wall of the cartilage lining the knee joint over injected with hyaluronic acid alone. The cartilage was rich in natural constituent of cartilage proteoglycan lining lining indicative of the success of the regeneration process. However, there was no significant improvement in the knees injected with acid hylaronic only after six months.
Remember the trial was not conducted on humans, but sheep and research is in the primary stage and Mesobalst Limited is working on this project further. But the results of preclinical trials have shown that mesoderm stem cell pbaruct can be very effective in the treatment and the regrowth of cartilage happen because of osteoarthritis in postmenopausal women.